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That would depend on how much you want your quilting to show. Several years ago, the 'big stitch' was popular where I live. It was a longer, bigger hand quilting stitch, done with thicker thread. If memory serves me correctly, several strands of embroidery floss was used too. Obviously you'll need a bigger needle for several strands of thread.
Take this one precaution...
My experience with embroidery floss is limited to using DMC for counted cross stitch designs. Every project I ever stitched was washed to remove the dirt and oils that accumulated after a year's worth of stitching.
To prevent the threads from running, especially the reds, I always added vinegar to my wash water. But that was a long time ago. I know more now and my time is at even more of a premium.
These days, I would first test for bleeding any embroidery thread I planned to use in a quilt. Especially if it's hand quilted. You've just got too much time involved in quilting to run the risk of a thread bleeding...and it does happen.
Stitch a bit on a practice sandwich. Then wash and dry it the way you will the finished quilt. If the embroidery floss passes this test, you're good to go!
Thank you for your question.
Readers, if you have any experience with using embroidery floss for hand quilting, please tell us about it using the 'comment' link below.